If it does, likely causes are too high of an operating temperature or too much glycerine/glycol/mineral oil in the mixture. This website and underlying databases are maintained and updated by Pesticide Action Network North America (PAN). 6 to 19 GD Teratology Pilot Studies (Gavage)   Completed, 6 to 15 GD Conventional Teratology (Gavage)  CAMEO Chemicals. En conclusion, on pourra dire que le propylène glycol nest pas considéré à lheure actuelle comme une substance toxique, mais quil convient de le consommer avec modération. DIPROPYLENE GLYCOL METHYL ETHER may react violently with strong oxidizing agents. Methyl- and ethyl-substituted ethylene glycol ethers can cause bone marrow depression, testicular atrophy, developmental toxicity, and immunotoxicity in animals. Dipropylene glycol is a colorless, nearly odorless liquid with a high boiling point and lo… Dose: 0, 800, 1500, 3000, 5000, OR 8000 MG/KG. [1, 24] Le propylène-glycol n’agit ni sur la fertilité ni sur le déve loppement des animaux. Standard toxicity studies conducted under good laboratory practices indicate a lack of genotoxic, developmental and reproductive hazards. Butylene Glycol, Hexylene Glycol, Ethoxydiglycol and Dipropylene Glycol are clear, practically colorless, liquids. Dipropylene glycol Nom français Dipropylène glycol N° CAS. Its low toxicity and solvent properties make it an ideal additive for perfumes and skin and hair care products. CASRN: 25265-71-8 Formula: C6-H14-O3 Synonyms/Common Names. The subacute percutaneous toxicity of dipropylene glycol monomethyl ether (DPM) in male rats dosed 5 days/week for 4 weeks under both occluded and unoccluded conditions has been assessed and compared to the percutaneous toxicity of ethylene glycol monomethyl ether (EGM). Propylene glycol toxicity is metabolized to compounds that are normal constituents of the citric acid cycle. DIPROPYLENE GLYCOL Safety Data Sheet according to Federal Register / Vol. The Dipropylene glycol, with the CAS registry number 25265-71-8, is also known as Oxydipropanol. Dipropylene glycol dimethyl ether, or DPDM, is a type of non-ionic solvent that is environmentally friendly and multifunctional. 2 … In addition, dipropylene glycol is hygroscopic and acts as a humectant, which means it absorbs water and increases hydration in products. 108-65-6 Dipropylene glycol methyl ether (DPM) CAS No. Dipropylene glycol is a mixture of three isomeric chemical compounds, 4-oxa-2,6-heptandiol, 2-(2-hydroxy-propoxy)-propan-1-ol, and 2-(2-hydroxy-1-methyl-ethoxy)-propan-1-ol. An official website of the United States government. (C88031B) In comparison, one person who developed symptoms of toxicity was receiving 213 grams of propylene glycol per day. Il existe plusieurs études concernant la toxicité du propylène glycol, par voie orale, par contact cutané, par inhalation et par intraveineuse. Nasal tissue. It is also a common ingredient in commercial fog fluid, used in entertainment industry smoke and haze machines. The site is secure. Oxybispropanol; Short-Term Toxicity. 107-98-2 Propylene glycol methyl ether acetate (PMA) CAS No. Is Dipropylene Glycol the same as Propylene Glycol? Acute oral toxicity Dipropylene Glycol : LD50 Oral: > 5,000 mg/kg Species: rat Ingestion of high doses may cause discomfort and irritation of the gastrointestinal tract and CNS depression (fatigue, dizziness and possibly loss of concentration, with collapse,coma and death in cases of severe over-exposure). and Dipropylene Glycol Butylene Glycol, Hexylene Glycol, Ethoxydiglycol, and Dipropylene Glycol are viscous liquids used in the cosmetic industry as humectants, emulsifiers, plasti- cizers, and solvents. Testing Status of Dipropylene glycol M88175 . This product is not intended for food use. The .gov means it's official. Synthétique; Fonctions CosIng.  Completed. Not even close. This emission, which is also called a release, does not always lead to exposure. No. Dipropylene glycol has been shown to be of low toxicity ( Whittington's Dictionary of Plastics ), but to be an active irritant of the skin and the eye area ( Cosmetic Database ). 29911-28-2 (35884-42-5) Dipropylene glycol methyl ether acetate (DPMA), CAS No 88917-22-0 Tripropylene glycol methyl ether (TPM), CAS No. There are many different types of compounds that belong to this family, such as butylene glycol, polyethylene glycol, ethylene glycol, and more. Propylène Glycol et Glycérine végétale, voici tout ce qu’il faut savoir lorsqu’on tente de faire artisanalement son propre liquide ou quand on s’informe sur une fiole vendue en boutique. Dose: R&M: 0, 0.5, 1.0, 2.0, 4.0, OR 8.0 % (5/S/S). May initiate the polymerization of isocyanates and epoxides. Table 1.  Completed. Chronic Toxicity and Carcinogenicity Did not cause cancer in laboratory animals. 34590-94-8. > Propylene glycol, unlike ethylene glycol, does not cause kidney failure. 77, No. Propylene glycol has been identified in at least 5 of the 1,416 NPL sites. Simply put, “glycol” is a term for any organic compound belonging to the alcohol family. (C88031) A wide variety of dipropylene glycol toxicity options are available to you, (TRP90005)  Completed, 6 to 15 GD Teratology Pilot Studies (Gavage)  (850639) Dose: R&M: 0, 0.5, 1.0, 2.0, 4.0 OR 8.0 % (10/S/S). It is a colorless, nearly odorless liquid with a high boiling point and low toxicity. Il est important de rappeler que pour ces études, ce sont des quantités très importantes de propylène glycol qui ont été administrées. Le propylène glycol (PG) ou propane-1,2-diol, appelé aussi 1,2-dihydroxypropane ou méthyl glycol, est un diol de formule chimique CH 3 –CHOH–CH 2 OH ayant de nombreux usages industriels ou agropharmaceutiques, à faible dose comme additif alimentaire et depuis peu dans les cigarettes électroniques (liquide à vapoter). Repeated Dose Toxicity Dose levels producing these effects were many times higher than any dose levels expected from exposure due to use. Plusieurs études par voies orale, cutanée ou sous-cutanée ont montré que le propylène-glycol n'est pas cancérogène chez le rat et la souris. Agent masquant; Solvant; Agent de contrôle de la viscosité ; Peut entrer dans la composition des parfums; Connaissances à ce jour. (C88031) Its low toxicity and solvent properties make it an ideal additive for perfumes and skin and hair care products. Federal government websites often end in .gov or .mil. Dipropylene glycol - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information: Note: See Working with the Information on this Page section below for important notes about this data. (TRP90006) 34590-94-8 2. (A31713) A robust toxicity database exists for the propylene glycol ethers that provide strong product safety support. Dans les e-liquides, il peut avoir des conséquences désagréables po… Liver. No. Propylene glycol poisoning is marked initially by CNS depression and an elevated osmolal gap and, later, by an increased anion gap. Synonyms. National Institute of Environmental Health Sciences, Testing Status of Dipropylene glycol M88175, 2 weeks (Dosed-Water)  Its key attributes include low toxicity, chemical stability and high solubility. Dipropylene Glycol Monomethyl Ether (DPGME), CAS Reg. 110-98-5 / 25265-71-8 N° CE. Dipropylene glycol is a small molecular weight synthetic solvent. 13 weeks (Dosed-Water)  58 / Monday, March 26, 2012 / Rules and Regulations Date of issue:methylethyl08/26/2018 Revision date: 08/26/2018 Supersedes: 06/01/2015 08/26/2018 EN (English US) Page 1 SECTION 1: Identification 1.1. Dipropylene glycol is a member of the glycol class of compounds.  Completed, Salmonella   Completed. 2 years (Dosed-Water)   Completed, 6 to 19 GD Conventional Teratology (Gavage)  Dipropylene glycol is a mixture of three isomeric chemical compounds, 4-oxa-2,6-heptandiol, 2-(2-hydroxy-propoxy)-propan-1-ol, and 2-(2-hydroxy-1-methyl-ethoxy)-propan-1-ol. The results of acute, subchronic, and chronic oral toxicity studies using a variety of animal species indicate a low order of toxicity for the Glycols. Origines. May generate flammable and/or toxic gases with alkali metals, nitrides, and other strong reducing agents. Sauf indication contraire, le propylène-glycol est commercialisé sous forme racémique. About the Chemical. 25498-49-1 & 20324-33-8 Propylene glycol methyl ether (PM) CAS No. Alibaba.com offers 117 dipropylene glycol toxicity products. Les données disponibles ne montrent pas d'effet cancérogène chez le rat et la souris. The reassessment decision is to maintain each of the two inert tolerance exemptions ''as-is''. Skin and Eye Irritation and References. (TER91013) 58 / Monday, March 26, 2012 / Rules and Regulations Issue date: 07/05/2020 Revision date: 07/05/2020 Supersedes: 04/17/2015 07/05/2020 EN (English US) Page 1 SECTION 1: Identification 1.1. DPM caused no significant changes in the clinical chemistry, haematology, or pathology, whereas EGM caused … It is completely soluble in water, and can also dissolve oils. It belongs to the product categories of Organic matters.This chemical's molecular formula is C 6 H 14 O 3 and molecular weight is 134.17.Its EINECS number is 246-770-3. The systemic toxicity of the ethylene-based glycol ethers is mediated by their metabolism to the corresponding alkoxyacetic acids. Dipropylene glycol n-butyl ether (DPnB), CAS No.  Completed. 6.1.2 Acute Toxicity ... Dipropylene glycol is a colorless, nearly odorless, and slightly viscous liquid with a high boiling point. [2][3], Dipropylene glycol finds many uses as a plasticizer, an intermediate in industrial chemical reactions, as a polymerization initiator or monomer, and as a solvent.  Completed. 77, No. Substance(s) Formule Nom Numéro CAS Numéro CE Numéro index Synonymes; C 3 H 8 O 2. It is also a common ingredient in commercial fog fluid, used in entertainment industry fog machines. Developmental Toxicity 203-821-4 / 246-770-3 Autres appellations Dipropylene glycol. OECD SIDS DIPROPYLENE GLYCOL METHYL ETHER UNEP PUBLICAIONS 1 FOREWORD INTRODUCTION DIPROPYLENE GLYCOL METHYL ETHER CAS N°: 34590-94-8 (Isomers: 13429-07-7, 20324 -32-7; 13588-28-8; and 5 5956-21-3) OECD SIDS DIPROPYLENE GLYCOL METHYL ETHER 2 UNEP PUBLICAIONS SIDS Initial Assessment Report for 12th SIAM (Paris, France, 27-29 June 2001) Chemical Name: DIPROPYLENE GLYCOL … Uses (TER90014) Diethylene glycol dibenzoate will be essentially non-volatile from water surfaces(1,SRC) based on an estimated Henry's Law constant of 3X10-12 atm-cu m/mole(SRC), developed using a fragment constant estimation method(3). Endocrine disruption (low), Non-reproductive organ system toxicity (low), and Irritation (skin, eyes, or lungs) (moderate) fragrance ingredient, solvent, viscosity decreasing agent, masking, and viscosity controlling. [2][3][4], InChI=1S/2C6H14O3/c1-5(7)3-9-4-6(2)8;1-3-5(7)9-6(8)4-2/h2*5-8H,3-4H2,1-2H3, InChI=1/2C6H14O3/c1-5(7)3-9-4-6(2)8;1-3-5(7)9-6(8)4-2/h2*5-8H,3-4H2,1-2H3, 4-oxa-2,6-heptandiol: InChI=1S/C6H14O3/c1-3-5(7)9-6(8)4-2/h5-8H,3-4H2,1-2H3, Except where otherwise noted, data are given for materials in their, https://en.wikipedia.org/w/index.php?title=Dipropylene_glycol&oldid=963169997, Chemical articles with multiple compound IDs, Articles with changed ChemSpider identifier, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License, This page was last edited on 18 June 2020, at 08:27. Intravenous injection of the substance into anaesthetized dogs results in a rapid drop in blood pressure which is unaffected by pretreatment of the animals with atropine or bilateral vagotomy [2]. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. Dipropylene glycol methyl ether Dipropylene glycol methyl ether (ACGIH:OSHA) Dowanol DPM Dowanol-50B Kino-red Methyl dipropanol Oxybispropanol methyl ether Ucar solvent 2LM. When a chemical is released from a large source, such as an industrial plant, or from a container, such as a drum or bottle, it enters the environment as a chemical emission. In animals, effects have been reported on the following organs after ingestion: Kidney. Dose: 0, 200, 800, 1500, 3000, OR 5000 MG/KG. > Although both propylene glycol and ethylene glycol are chemically classified as glycols and both are metabolized, as a first step, by the same enzyme in the liver (alcohol dehydrogenase), ethylene glycol has a much high toxicity. Le propylène-glycol existe sous deux formes isomériques, le R-(-)-propane-1,2-diol (CAS 4254-14-2) et le (S)-(+)-propane-1,2-diol (CAS : 4254-15-3). The systemic toxicity of dipropylene glycol monomethyl ether is characterized by central nervous system (CNS) depression [1]. Before sharing sensitive information, make sure you're on a federal government site. The local toxic effects R: 0, 2, 500, 10, 000, or 10, 000 ppm; M: 0, 10, 000, 20, 000 or 40, 000 ppm; 50/SEX/DOSE. Micronucleus  What is ethylene glycol? 30% distilled water: 35% dipropylene glycol: 35% triethylene glycol (long-lasting fog) 30% distilled water: 70% dipropylene glycol (dense fog) The resulting smoke should not smell "burnt." A glycol, which may also be referred to as a diol, is comprised of two hydroxyl (−OH) groups attached to different carbon atoms. Identification Product form : Substance Trade name : DIPROPYLENE GLYCOL CAS-No. It is a colorless, nearly odorless liquid with a high boiling point and low toxicity. 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