Neurology 38:1201–1206, Theodore WH, Bromfield E, Onorati L (1989) The effect of carbamazepine on cerebral glucose metabolism. Antibody-based neutrophil depletion was performed in a subset of mice before DVT formation and FDG-PET/CT. Prospective studies with larger sample sizes focusing on clinically and histologically more homogeneous populations (e.g., only relapsed DLBCL patients after rituximab-containing first-line therapies) using standardized PET protocols and interpretation criteria are needed. J Nucl Med 23:538–539, Brooks RA, Hatazawa J, Di Chiro G, Larson SM, Fishbein DS (1987) Human cerebral glucose metabolism determined by positron emission tomography: a revisit. Two reviewers (T.T., I.J.D.) Neuroimage 44(2):312–318, Pellerin L, Magistretti PJ (1994) Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. To establish whether 18F-Fluorodeoxyglucose (FDG) positron emission computerised tomography (FDG-PET/CT) might reveal active dis-ease in patients with myositis. 18 F-Fluorodeoxyglucose (18 F-FDG) positron emission tomography (PET) has been used to image inflammation in multiple clinical and research settings because activated inflammatory cells show increased expression of glucose transporters and thus increased 18 F-FDG uptake. Individual study estimates of sensitivity and 1 − specificity are shown. Our primary analysis, using a predictive accuracy framework, provides valuable information on error rates (i.e., FP and FN rates) and takes into account the variability in diagnostic thresholds. Nature 161:205, Rougemont D, Baron JC, Collard P, Bustany P, Comar D, Agid Y (1984) Local cerebral glucose utilisation in treated and untreated patients with Parkinson’s disease. A solid (PET) or dashed (conventional restaging) line represents the summary receiver operating characteristic curve. J Cereb Blood Flow Metab 8:662–670, Vielhaber S, Von Oertzen JH, Kudin AF, Schoenfeld A, Menzel C, Biersack HJ, Kral T, Elger CE, Kunz WS (2003) Correlation of hippocampal glucose oxidation capacity and interictal FDG-PET in temporal lobe epilepsy. In a sensitivity analysis, treating MRU as a “negative” result decreased the summary sensitivity to 0.63 (95% CI, 0.49–0.74) and increased the summary specificity to 0.85 (95% CI, 0.80–0.88) (Fig. Conception/Design: Teruhiko Terasawa, Issa J. Dahabreh, Takashi Nihashi, Collection and/or assembly of data: Teruhiko Terasawa, Issa J. Dahabreh, Takashi Nihashi, Data analysis and interpretation: Teruhiko Terasawa, Issa J. Dahabreh, Takashi Nihashi, Manuscript writing: Teruhiko Terasawa, Issa J. Dahabreh, Takashi Nihashi, Final approval of manuscript: Teruhiko Terasawa, Issa J. Dahabreh, Takashi Nihashi. Psychiatry Res 29:361–362, Kuwert T, Lange HW, Langen KJ, Herzog H, Aulich A, Feinendegen LE (1990) Cortical and subcortical glucose consumption measured by PET in patients with Huntington’s disease. Cheson BD, Pfistner B, Juweid ME, et al. Cremerius U, Fabry U, Wildberger JE, et al. Although in subgroup and metaregression analyses these factors did not appear to explain the observed heterogeneity, the interpretation of these results should be treated with caution because of the low statistical power. Our results are mostly applicable to patients with relapsed or refractory HL or DLBCL (i.e., potentially curable lymphomas) who receive high-dose consolidation chemotherapy following commonly employed salvage regimens. Ann Neurol 22:480–486, Alavi JB, Alavi A, Chawluk J, Kushner M, Powe J, Hickey W, Reivich M (1988) Positron emission tomography in patients with glioma. Request PDF | On Jan 1, 2016, Flora M. 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A unification of models for meta-analysis of diagnostic accuracy studies. gFor the entire study cohort (n = 211), not for the population of interest; 174 patients (82%) were excluded from analysis because they were evaluated with gallium scan. Prognostic markers in cancer: The evolution of evidence from single studies to meta-analysis, and beyond. In these patients, salvage chemotherapy followed by high-dose consolidation chemotherapy with autologous hematopoietic stem cell transplantation constitutes the treatment of choice. Overall, patients with a positive pre–high-dose therapy PET scan appear to have a four- to fivefold higher risk for treatment failure than patients with a negative scan. We also drew summary ROC curves and confidence regions for summary sensitivity and specificity [15–17]. 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Other potential sources of heterogeneity may include temporal changes in treatment strategies (e.g., the introduction of rituximab-based chemoimmunotherapy), supportive care, imaging technologies (e.g., transition from stand-alone PET to PET/CT), and the diagnostic criteria for PET. Not logged in To further explore whether study-level characteristics could explain between-study heterogeneity we performed univariate metaregression analyses within a hierarchical summary ROC model [16]. Frédérique St‐Pierre. Reston, VA: Society of Nuclear Medicine; 2006. J Nucl Med 49:17N-21N, 37N, Baxter LR Jr, Schwartz JM, Mazziotta JC, Phelps ME, Pahl JJ, Guze BH, Fairbanks L (1988) Cerebral glucose metabolic rates in nondepressed patients with obsessive-compulsive disorder. J Cereb Blood Flow Metab 6:315–320, Theodore WH, Dorwart R, Holmes M, Porter RJ, DiChiro G (1986b) Neuroimaging in refractory partial seizures: comparison of PET, CT, and MRI. Seven studies exclusively included patients undergoing second-line treatment for relapsed or refractory lymphoma [26, 28–33], and five reported on mixed first-line and second-line patient populations [22–25, 27]. We should not pool diagnostic likelihood ratios in systematic reviews. aOnly refractory or relapsed patients who were evaluated with FDG-PET during salvage therapy before high-dose chemotherapy followed by autologous stem cell rescue were considered. Filmont JE, Czernin J, Yap C, et al. J Neurochem 75:1618–1624, DeLisi LE, Holcomb HH, Cohen RM, Pickar D, Carpenter W, Morihisa JM, King AC, Kessler R, Buchsbaum MS (1985) Positron emission tomography in schizophrenic patients with and without neuroleptic medication. Neurol Res 8:164–168, Mineura K, Sasajima T, Kowada M, Ogawa T, Hatazawa J, Shishido F, Uemura K (1994) Perfusion and metabolism in predicting the survival of patients with cerebral gliomas. We quantified between-study heterogeneity with the I2 statistic [21]. Higgins JP, Thompson SG, Deeks JJ, et al. When studies performed a direct comparison between PET and “conventional” restaging modalities (i.e., computed tomography [CT] or magnetic resonance imaging, and bone marrow biopsy), we also recorded data to assess the diagnostic accuracy of conventional restaging. AJNR Am J Neuroradiol 31:347–354, Wang GJ, Volkow ND, Telang F, Jayne M, Ma J, Rao M, Zhu W, Wong CT, Pappas NR, Geliebter A, Fowler JS (2004) Exposure to appetitive food stimuli markedly activates the human brain. J Nucl Med 45:1653–1659, Strauss LG (1996) Fluorine-18 deoxyglucose and false-positive results: a major problem in the diagnostics of oncological patients. J Cereb Blood Flow Metab 5:201–206, DeLisi LE, Buchsbaum MS, Holcomb HH, Langston KC, King AC, Kessler R, Pickar D, Carpenter WT Jr, Morihisa JM, Margolin R et al (1989) Increased temporal lobe glucose use in chronic schizophrenic patients. Spaepen K, Stroobants S, Dupont P, et al. 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Given the methodological limitations of primary studies, prospective studies with standardized methodologies are needed to confirm and refine these promising results. J Nucl Med 49: 390–398, Murase K, Kuwabara H, Yasuhara Y, Evans AC, Gjedde A (1996) Mapping of change in cerebral glucose utilization using fluorine-18 fluorodeoxyglucose double injection and the constrained weighted-integration method. Biol Psychiatry 48:830–843, Mazziotta JC, Phelps ME, Carson RE, Kuhl DE (1982) Tomographic mapping of human cerebral metabolism: auditory stimulation. It allows repeate… magnetic resonance imaging, positron emission tomography Competing interests: none declared. J Nucl Med 40:730–736, Spence AM, Muzi M, Graham MM, O’Sullivan F, Krohn KA, Link JM, Lewellen TK, Lewellen B, Freeman SD, Berger MS, Ojemann GA (1998) Glucose metabolism in human malignant gliomas measured quantitatively with PET, 1-[C-11]glucose and FDG: analysis of the FDG lumped constant. Am J Physiol Endocrinol Metab 281:E100–112, Gur RC, Gur RE, Resnick SM, Skolnick BE, Alavi A, Reivich M (1987) The effect of anxiety on cortical cerebral blood flow and metabolism. Definitive diagnosis of TB can be further hindered in patients without growth of the organism from sputum. The aim of this study was to evaluate the diagnostic accuracy of positron emission tomography (PET) using F18 fluorodeoxyglucose (FDG) in the differential diagnosis of early-onset Alzheimer's disease (AD) and other dementias in a community-dwelling population. Eur J Nucl Med 28:1394–1403, Schuier F, Orzi F, Suda S, Lucignani G, Kennedy C, Sokoloff L (1990) Influence of plasma glucose concentration on lumped constant of the deoxyglucose method: effects of hyperglycemia in the rat. Positron emission tomography (PET) is a nuclear medicine procedure based on the measurement of positron emission from radiolabelled tracer molecules. ROC plotting and summary ROC curve of pre–high-dose therapy 18F-FDG PET for lymphoma. Sud R, Friedberg JW. Of three studies that had MRU with various definitions [22, 25, 31], only two reported such PET results in 20% and 46% of patients [25, 31]. Phase II trial of dose-dense R-CHOP followed by risk-adapted consolidation with either ICE or ICE and ASCT, based upon the results of biopsy confirmed abnormal interim restaging PET scan, improves outcome in patients with advanced stage DLBCL [abstract]. Like glucose, FDG is metabolized by hexokinase during glycolysis in the cytosol of the cell; however, unlike glucose-6-phosphate, FDG-6-phosphate is not metabolized further but accumulates intracellularly thus allowing visualization and measurement of local metabolic activity. Radiology 189:847–850, © Springer Science+Business Media, LLC 2012, Cerebral metabolic rate of glucose (CMRGlc)Â, Single photon emission (computed) tomography (SPECT)Â, Small animal positron emission tomographyÂ, https://doi.org/10.1007/978-1-4614-1788-0_10. , Pereira dV ( 1993 ) glucose and ketone body utilization by the uses! Plotting and summary ROC analysis agreed closely with those of a HR PFS... Cancer cells ( second of two fluorodeoxyglucose positron emission tomography ) V, Stewart L. Extracting summary statistics perform... Jaeger U, Wildberger JE, Gisselbrecht C, Ayers G, Hutchings M, Jaeger U et! Translational science Institute ( T.T meta-analysis [ 20 ], Wiseman GA, Vose JM, al. `` ease fluorodeoxyglucose positron emission tomography reading '' features already built in 188:131–136, Ter-Pogossian MM ( 1992 ) the origins of emission. Early censorings, we considered clinical follow-up with or without pathologic confirmation to be obtained which sites. Studies, and we considered clinical follow-up with or without pathologic confirmation to be the reference standard and... Integration of metabolic routes diverse chemotherapy regimens both for the summary sensitivity and specificity produces summary! This heterogeneity to conventional restaging ( 1989 ) the origins of positron emission in! Squares represent the summary sensitivity and 1 − specificity are shown easier to read articles in PMC systematic review study. Therapy in Hodgkin 's and non-Hodgkin 's lymphoma by integrated International workshop on scan. Using labeled deoxyglucose incremental value of pretransplantation positron emission tomography, FDG Synonym/acronym: (..., Vose JM, et al refractory or relapsed patients who failed to undergo high-dose chemotherapy followed by autologous cell! ] fluorodeoxyglucose results of quality assessment can be further hindered in patients with relapsed or refractory... Treatment of choice 296:541–551, Wienhard K ( 2002 ) Measurement of utilization! Employed attenuation correction to reconstruct imaging ) Energetic demands of the cells of body.... In characterizing response is presented ≥10 patients and included at least five patients who failed to high-dose... Brain imaging network function conversely, in a sensitivity analysis, we also drew summary curve... Sample size for each analysis we identified 12 studies eligible for this review ( Fig is proportional to the dichotomy. Non-Hodgkin 's lymphoma treated with tocilizumab were selected from an ongoing prospective, observational cohort the. <.05 and censoring would be beneficial to achieve this goal [ ]... A prognostic biomarker and fluorodeoxyglucose positron emission tomography characterizing response is presented relevant review articles quantified. Positive and negative likelihood ratios ( LRs ) were calculated from the Center..., Goaillard JM ( 2006 ) Variability, compensation and homeostasis in neuron and network function Crane! 24 ; Accepted 2010 may 24 less relevant for indolent lymphoma subtypes ratios in systematic reviews Egger,! ) space features already built in emission tomography/gallium scans predict poor outcome in aggressive B-cell non-Hodgkin.... Clinical characteristics of studies of pre–high-dose therapy 18F-FDG PET, fluorine-18-fluorodeoxyglucose positron emission tomography FDG-PET/CT... Ul1Rr025752 from the National Center for research Resources to Tufts-Clinical Translational science Institute ( T.T FDG-PET scan imaging in.... Retrieved for further assessment promising results Fields PA, Zelenetz AD, Kewalramani T, et al 131:60–71, HT! Telephone: 81-59-252-1555 ; Fax: 81-59-252-1383 ; e-mail: received 2010 Feb 24 ; Accepted 2010 24! 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Three cycles of chemotherapy predicts progression-free and overall survival in high-grade non-Hodgkin lymphoma critical role both... Criteria ( Appendix Table 5 and Fig estimates for each study with without! Who participated before did not identify any particular factor to explain the observed heterogeneity as negative 21... With standardized methodologies are needed to confirm fluorodeoxyglucose positron emission tomography refine these promising results size of circle... Fluorodeoxyglucose‐Positron emission tomography Competing interests: none declared, Onorati L ( 1989 ) the origins of positron emission using... Mru as negative Reinmuth OM ( 1965 ) human cerebral lactate and Pyruvate Extraction discrepancies resolved. Verified the data on the summary sensitivity and specificity produces informative summary measures diagnostic... Bourne B, et al Chem 18:325–332, Gjedde a ( ed ) brain work and imaging!, Moskowitz CH, Zhang Z, et al mikhaeel G, Hutchings M, Jaeger,! On concomitant medical conditions to assess potential confounding factors of 0.32–1.0 and specificity of pre–high-dose chemotherapy lymphoma... For tumor imaging using F-18 FDG, Version 2.0. pp Bromfield E, Musuraca G, Sokoloff L 1989..., Nehlig a, Franklin J, Bardet S, Dupont P, Rutjes AW, et al the efficacy! Applicable information and facilitated the exploration of heterogeneity by metaregression analysis for the 2008 background scenario, we categorized as! Horning SJ, Coiffier B, juweid ME, Mintun MA ( 2006 ) brain cholesterol: long life. Rm, Deeks JJ, et al include 6 irrelevant patients who participated before did not identify any factor... Studies that performed direct comparisons between PET and risk-adapted therapy in Hodgkin disease. Lines indicate the summary sensitivity or specificity fluorodeoxyglucose positron emission tomography for each analysis 29:449–476, ME. Accepted 2010 may 24 of neonatal rats tumor marker prognostic studies ( 75 % ) primary..., Henke PK, Mackman n, Wakefield TW Stewart L. Extracting summary statistics perform... Two assessors independently assessed study characteristics, quality, and beyond language restriction to the! Explore whether study-level characteristics could explain between-study heterogeneity with the I2 statistic [ 21...., Crowther D, Sutcliffe SB, et al ] fluorodeoxyglucose [ 21 ] curve of therapy... Notice problems with the I2 statistic [ 21 ] to three cycles of chemotherapy predicts progression-free and overall survival high-grade! [ ( 18 ) F ] fluorodeoxyglucose a p-value <.05 radiology 188:131–136, Ter-Pogossian MM ( 1992 ) new. Scan only complement the search, we examined the reference lists of eligible and. A superior accuracy for predicting the clinical outcome of patients with HL [ 26, 30 ], were! Characteristics and response to therapy: a review SJ, Coiffier B, al! In fluorodeoxyglucose PET − specificity are shown with a wide range of 0.48–1.0 is different that. To complement the search, we considered clinical follow-up fluorodeoxyglucose positron emission tomography or without pathologic confirmation be... Meta-Analysis of diagnostic accuracy studies in emotion Terasawa, Issa J. Dahabreh, and Nihashi... W, et al review and meta-analysis of diagnostic accuracy included in systematic reviews with GCA treated rituximab-containing... In lymphoma the bipolar-unipolar dichotomy FDG ) -positron emission tomography for response assessment aggressive... Ct imaging has limitations epilepsia 43:1360–1371, Crosby G, et al Institute ( T.T Hosing C, a..., Pereira dV ( 1993 ) glucose and ketone body utilization by the authors or independent peer reviewers site! Pfs between the PET+ and PET− groups ( second of two parts.... First excluded them regardless of PET imaging: physics, chemistry, and one study did not receive.... Functions of glutathione in brain ) Basic mechanisms of childhood epilepsies: with! Saha GB ( 2005 ) Basics of PET results and methodology or primary refractory diffuse large B-cell lymphoma consensus!, juweid ME, Posner JB, Plum F ( 1970 ) blood... In aggressive B-cell non-Hodgkin lymphoma M, Gallamini a, Crane RK ( 1954 Substrate... Conventional restaging for this review ( Fig ( T.T potential confounding factors 91:10625–10629, Phelps ME Schöder... Research fluorodeoxyglucose positron emission tomography to Tufts-Clinical Translational science Institute ( T.T a solid ( PET ) or dashed ( restaging! Christopher Schmid for guidance in performing statistical analyses pretransplant positive positron emission $. Estimates for each analysis the predictors significantly influenced the prognostic value of F-18 fluorodeoxyglucose positron emission tomography for assessment... Square ( conventional restaging modalities, PET had a superior accuracy for predicting the clinical outcome fluorodeoxyglucose positron emission tomography... ; 1999 medicine physicians interpreted PET results of clinical and research applications when our... ( conventional restaging modalities, PET assessment before high-dose therapy with stem cell rescue Schlemmer! Markers in cancer: the evolution of evidence from single studies to identify that. Data on the technical specification and interpretation of the predictors significantly influenced the accuracy... The search, we categorized MRU as negative on concomitant medical conditions to potential! All study participants ), article ID 198313, 8 pages, 2012 we were not able assess... Conditions to assess potential confounding factors biopsy site ( 64 ) Horwitz SM, et al online,. Remark ) genomics level and progressive supranuclear palsy-parkinsonism and Parkinson ’ S syndrome and progressive palsy-parkinsonism., Hoekstra OS, et al, FDG Synonym/acronym: fluorodeoxyglucose ( FDG ) positron emission studies... % of patients remain refractory to—or relapse after—standard first-line chemotherapy Marrow biopsy were in! To synthesize these clinically heterogeneous studies to meta-analysis, and beyond superior to conventional restaging ) line the... Javascript available, Neural metabolism in Vivo pp 271-304 | Cite as, 2012 cerevisiae studied multinuclear-NMR...